论文部分内容阅读
目的观察Ｃａ２＋及脑神经递质与癫痫发作的关系。方法在海人酸致痫大鼠、青霉素大脑皮层致痫家兔及癫痫患儿，用脑电分析技术及荧光分光光度法，测定脑内递质、Ｃａ２＋，Ｍｇ２＋含量及升高血钙对动物痫样放电的影响。结果①海人酸致痫大鼠及癫痫患儿发作时，脑电功率值明显增加（Ｐ＜０．０１），脑涨落图分析技术（ＥＴ）的Ｓ谱线中反映ＧＡＢＡ的Ｓ１谱线降低，反映Ｇｌｕ和Ａｃｈ的Ｓ２及Ｓ５谱线增加，Ｓ１、Ｓ２逆转（即Ｓ２＞Ｓ１，正常时Ｓ１＞Ｓ２），并显示癫痫发作时有Ｓ５极大值。②癫痫患儿及致痫家兔血清Ｃａ２＋含量降低。③升高血Ｃａ２＋使青霉素致痫家兔痫样放电的潜伏期缩短，频率及幅度降低；同时使血清Ｃａ２＋，Ｍｇ２＋含量增加，但钙镁含量比值不变；脑组织中除Ｃａ２＋，Ｍｇ２＋含量增加外，两者比值也增加。结论脑内兴奋性递质增加，抑制性递质减少，血Ｃａ２＋降低可导致癫痫发作或使癫痫易于发作，补充钙剂对癫痫发作有抑制作用。
Objective To observe the relationship between Ca2 + and brain neurotransmitters and seizures. Methods Echocardiography and fluorescence spectrophotometry were used to detect the contents of neurotransmitter, Ca2 + and Mg2 + in brain of hippuric acid-induced epileptic rats and penicillin-induced cerebral cortex in rabbits and epilepsy. Impact of epileptiform discharges. Results ① The values of EEG in the epileptic seizures and the epilepsy seizure increased significantly (P <0.01). The S-curve of the brain edema analysis (ET) showed that the S1 spectrum of GABA decreased , Reflecting the increase of S2 and S5 lines of Glu and Ach, the reversal of S1 and S2 (ie, S2> S1, S1> S2 at normal) and the S5 maxima at seizure onset. ② Epilepsy in children with serum creatinine and reduce the level of Ca2 +. ③Increased blood Ca2 + induced a decrease in the latency and frequency of epileptiform discharge in penicillin-induced epilepsy rabbits, meanwhile, the contents of Ca2 + and Mg2 + in serum increased, but the contents of Ca2 + and Mg2 + remained unchanged. Except Ca2 + and Mg2 + , The ratio between the two has also increased. Conclusions Increased excitatory neurotransmitters in the brain, decreased inhibitory neurotransmitters, reduced blood Ca2 + may lead to seizures or epilepsy prone to seizures, and calcium supplementation may have an inhibitory effect on seizures.