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目的探讨充血性心力衰竭(CHF)患者甲状腺激素水平与心功能的关系。方法用放射免疫法(RIA)分别测定72例CHF患者(CHF组)和53例(对照组)的血清促甲状腺素(TSH)、总三碘甲状腺原氨酸(TT3)、总四碘甲状腺原氨酸(TT4)、游离甲状腺原氨酸(FT3)、游离甲状腺素(FT4)水平,并作超声心动图测定左室射血分数(LVEF)。结果CHF组TT3、FT3水平明显低于对照组(P<0.05);CHF组TT3水平与LVEF呈显著正相关(P<0.01)。结论甲状腺激素水平的变化可作为判断CHF严重程度的参考指标,对治疗及预后有一定临床意义。
Objective To investigate the relationship between thyroid hormone levels and cardiac function in patients with congestive heart failure (CHF). Methods Serum thyrotropin (TSH), total triiodothyronine (TT3), total tetraiodothyronine (GTPA) in 72 patients with CHF and CHF in 53 patients were determined by radioimmunoassay (RIA) TT4, FT3 and FT4, and left ventricular ejection fraction (LVEF) was measured by echocardiography. Results The levels of TT3 and FT3 in CHF group were significantly lower than those in control group (P <0.05). There was a significant positive correlation between TT3 level and LVEF in CHF group (P <0.01). Conclusion The change of thyroid hormone level can be used as a reference index to judge the severity of CHF, which has some clinical significance for treatment and prognosis.