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目的:对比国产和进口头孢哌酮的药物动力学,为临床选药提供依据.方法:以非那西丁为内标,以HPLC法研究国产和进口头孢哌酮的药物动力学;以琼脂平板稀释法考察其体外抑菌活性;观察临床疗效和不良反应.结果:两组的药学参数、MIC值及有效率均无统计学差异.结论:国产和进口头孢哌酮的药物动力学及药效学相似.
OBJECTIVE: To compare the pharmacokinetics of domestic and imported cefoperazone to provide a basis for clinical drug selection.METHODS: Phenacetin was used as an internal standard to study the pharmacokinetics of domestic and imported cefoperazone by HPLC. Dilution method was used to investigate the antibacterial activity in vitro and the clinical curative effect and adverse reaction were observed.Results: There was no significant difference in the pharmacological parameters, MIC value and effective rate between the two groups.Conclusion: The pharmacokinetics and pharmacodynamics of domestic and imported cefoperazone Similar learning.