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目的探讨双黄连制剂致药品不良反应(ADR)的特点及相关因素,为临床合理用药提供参考.方法检索2000-2011年国内医药期刊报道的双黄连制剂致 ADR 案例,并进行统计、分析.结果双黄连制剂致 ADR 主要表现为全身红斑,头晕,恶心呕吐,泛酸,皮肤潮红、瘙痒,眼睑浮肿,畏冷、寒战.其次为心前区不适、胸闷等症状,手指关节、腕、肩、肘、膝关节疼痛,出血性结肠炎,过敏性休克.结论临床应重视对双黄连制剂的合理应用,避免和减少 ADR 的发生.“,”Objective:To explore ShuangHuangLian preparation the adverse drug reaction (ADR) features and related factors, and provide reference for clinical rational drug use. Methods:Retrieval 2000-2011 domestic medical journal reported ShuangHuangLian preparation to ADR cases, and statistics, analysis.Results and Conclusion:ShuangHuangLian oral liquid ADR caused mainly for systemic lupus, dizziness, nausea and vomiting, pantothenic acid, skin rubeosis, itching, eyelid edema, fear cold, chil. Folowed by the area before the heart is unwel, the bosom is frowsty wait for a symptom, finger joints, wrist, shoulder, elbow and knee pain, hemorrhagic colitis, anaphylactic shock. Conclusion: clinical attention should be paid to the reasonable application of ShuangHuangLian preparation, avoid and reduce the occurrence of ADR.