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乙酰吉他霉素对临床分离的革兰氏阳性球菌有较好的抑菌活力，其对金葡球菌、β－溶血性链球菌、表葡球菌的ＭＩＣ_（５０）分别为１、０．２２和４ｍｇ／Ｌ，对耐红霉素、青霉素的金葡球菌、表葡球菌半数以上较敏感，与吉他霉素相似，但其对革兰氏阴性菌无明显作用。乙酰吉他霉素对小鼠实验性细菌感染有明显保护作用。对金葡球菌、肺炎双球菌感染小鼠口服用药的ＥＤ_（５０）分别为７９．６和２５．１ｍｇ／ｋｇ。其疗效与吉他霉素、麦白霉素、乙酰螺旋霉素相似。乙酰吉他霉素小鼠１次口服的ＬＤ_（５０）＞１５ｇ／ｋｇ，与吉他霉素相比毒性无差异。
Acetylskeptomycin had a good antibacterial activity against Gram-positive cocci isolated clinically. The MIC_ (50) against Staphylococcus aureus, β-hemolytic streptococcus and Staphylococcus epidermidis were 1, 0.22 and 4mg / L, erythromycin erythromycin, penicillin Staphylococcus aureus, more than half of Staphylococcus aureus more sensitive, and similar to the genera toxin, but its Gram-negative bacteria had no significant effect. Acetylthymmycin has obvious protective effect on experimental bacterial infection in mice. The oral administration of Staphylococcus aureus and Streptococcus pneumoniae mice ED_ (50) were 79.6 and 25.1mg / kg. The curative effect and the guitar, malimin, acetylspiramycin similar. Acetylglycine in mice once oral LD_ (50)> 15g / kg, compared with the no significant difference in the virulence.