论文部分内容阅读
目的探讨知柏地黄丸对解脲脲原体(ureaplasma urealyticum,Uu)感染不育患者精子膜尿激酶型纤溶酶原激活因子(urokinase-type plasminogen activator,u PA)及精子质量的影响。方法 2011年7月—2013年8月于东莞市人民医院男科门诊及生殖科就诊的不育患者共180例,其中精液Uu培养阳性患者130例,Uu培养阴性患者50例。Uu培养阳性患者按就诊顺序随机分为知柏地黄丸治疗组(观察组)72例与西药治疗组(对照组)58例。所有患者均服用敏感抗生素2周,观察组同时加用知柏地黄丸(6 g/次,2次/天);对照组加服Vit E(100 mg/次,2次/天)及ATP(40 mg/次,2次/天)。2组均治疗90天,治疗前后检测精液参数及精子膜u PA含量并作对比分析。结果与Uu感染阴性患者比较,Uu感染阳性患者精子活率、活力及正常形态精子百分率均降低,精子膜u PA含量也降低,差异均有统计学意义(均P<0.05);而精子密度差异无统计学意义(P>0.05)。观察组与对照组治疗前精子膜u PA含量及精子各指标比较,差异无统计学意义(P<0.05);与本组治疗前比较,两组精子膜u PA含量、精子活率、精子活力及精子正常形态均明显增高,差异有统计学意义(P<0.05,P<0.01);治疗后,与对照组比较,观察组精子膜u PA含量增高更明显,差异有统计学意义(P<0.05)。结论 Uu感染会降低精子膜u PA含量,使精子活力下降;知柏地黄丸可能通过修复Uu损伤的精子膜,促使精子膜u PA含量升高,提高精子受精能力,有效治疗Uu感染性不育症。
Objective To investigate the effect of Zhibaodihuangwan on spermatogenic membrane urokinase-type plasminogen activator (uPA) and sperm quality in infertile patients with ureaplasma urealyticum (Uu) infection. Methods From July 2011 to August 2013, 180 infertile patients were treated in male outpatient department and reproductive department of Dongguan People’s Hospital. Among them, 130 were positive for Uu semen and 50 were negative for Uu. Uu culture-positive patients were randomly divided into Zhibelihuangwan treatment group (observation group) 72 cases and western medicine treatment group (control group) 58 cases. All patients were treated with sensitive antibiotics for 2 weeks. The observation group was treated with Zhibai Dihuang Wan (6 g / time, twice daily / day); the control group was given Vit E (100 mg / time, twice daily) and ATP 40 mg / time, 2 times / day). Both groups were treated for 90 days, before and after treatment to detect sperm parameters and sperm membrane u PA content and comparative analysis. Results Compared with patients with negative Uu infection, the sperm motility, vitality and sperm percentage of normal Uu-infected patients decreased and the content of sperm u PA also decreased (all P <0.05). However, the differences in sperm density No statistical significance (P> 0.05). There was no significant difference between the observation group and the control group before treatment, and there was no significant difference between the two groups (P <0.05). Compared with before treatment, uPA content, sperm motility, sperm motility (P <0.05, P <0.01). After treatment, compared with the control group, the content of u PA in the observation group was more obvious, the difference was statistically significant (P < 0.05). Conclusion Uu infection can reduce sperm membrane u PA content and decrease sperm motility. ZBP can repair uu damaged sperm membrane, promote the membrane u PA content of sperm membrane and enhance sperm fertilization ability, which can effectively treat Uu infertility infertility disease.