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目的:建立中药材稳态提取工艺中平衡群体的数学模型并进行实验验证。方法:运用信息熵及遗传统计学原理,以同一GAP产地鱼腥草植株间挥发油GC指纹图谱信息量变异系数为枢纽,建立中药稳态提取工艺中平衡群体的数学模型,并进行实验验证。结果:建立了适宜中药及制剂稳态提取工艺中平衡群体的数学模型;以同一产地鱼腥草为模型药物获得该产地的遗传平衡群体为29 683株(约118.7 kg)。结论:在GAP质控模式下,进一步用鱼腥草的株间Hardy-Weinberg平衡群体来控制其质量稳定性,为中药稳态提取工艺的建立及质控奠定新的理论与实验基础。
OBJECTIVE: To establish the mathematical model of the balanced population in the steady-state extraction process of Chinese herbal medicines and verify the experimental results. Methods: Using information entropy and genetic statistics, taking the variation coefficient of GC fingerprint of volatile oil between Houttuynia cordata plants in the same GAP origin as the hinge, a mathematical model of the balanced population in the steady-state extraction process was established and verified by experiments. Results: A mathematical model was established for the balanced population in steady state extraction of traditional Chinese medicine and its preparations. The genetic equilibrium population of this Houttuynia source in the same place as the model drug was 29 683 (about 118.7 kg). Conclusion: Under the GAP quality control mode, Hardy-Weinberg equilibrium population of Houttuynia cordata was further used to control its quality stability, which laid a new theoretical and experimental foundation for the establishment and quality control of the steady-state extraction process of Chinese traditional medicine.