Natural Compound Curcumin Corrects the Gating Defect of G551DMutant Cystic Fibrosis Transmembrane

• 作 者: HAO Li-ming LIU Xin XU Li-na Z
• 机 构: MembraneChannelResearchLaboratory,China-JapanUnionHospital,SchoolofBasicMedicine,CollegeofLifeScienc
• 出 处: 高等学校化学研究：英文版
• 发表日期: 2008年1期
• 关键词: 分析方法 囊肿性纤维化 遗传性胰腺病 化合物 药物 Cystic fibrosis CFTR Mutation Natural compound Activat
• 基金项目: Supported by the National Natural Science Fund for Distinguished Young Scholars（No.30325011）, the National Natural Science Foundation of China（Nos.30470405, 30570864, 30670477）, Distinguished Young Sc

In the present study, we identified the natural compound curcumin to be an effective G551D-CFTR activator by cell-based fluorescent assay and electrophysiological measurement. We demonstrated that curcumin can restore the impaired chloride conductance of