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目的：探讨三氧化二砷（Ａｓ２Ｏ３） 治疗慢性粒细胞性白血病（ＣＭＬ） 的机制。方法：以ＣＭＬ细胞系Ｋ５６２ 为模型，通过细胞增殖、活力检测、形态学观察、肿瘤集落形成的琼脂糖凝胶电泳等检验。结果：经≥２．５μｍｏｌ／ＬＡｓ２Ｏ３ 处理的Ｋ５６２ 细胞可出现增殖受抑和凋亡的形态学改变及ＤＮＡ片段化。结论：Ａｓ２Ｏ３ 能有效地诱导Ｋ５６２ 细胞凋亡。
Objective: To investigate the mechanism of arsenic trioxide (As2O3) in treating chronic myelogenous leukemia (CML). Methods: The CML cell line K562 was used as a model and tested by cell proliferation, viability test, morphological observation and colony formation by agarose gel electrophoresis. Results: K562 cells treated with ≥2.5μmol / L As2O3 exhibited morphological changes and DNA fragmentation with suppressed proliferation and apoptosis. Conclusion: As2O3 can effectively induce apoptosis of K562 cells.