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目的：为了探讨恶性淋巴瘤（ＭＬ）患者血浆Ｄ－二聚体（ＤＤ）、血管性血友病因子（ＶＷＦ）水平变化的临床意义．方法：用ＥＬＩＳＡ双抗体夹心法对５２例ＭＬ患者血浆ＤＤ，ＶＷＦ水平进行了检测．结果：①初发ＭＬ患者血浆ＤＤ，ＶＷＦ水平［（０．１７３４±０．１１９４）ｍｇ／Ｌ，（２０４．１２±７８．８１）％］明显高于对照组［（０．１０３０±０．０２９１）ｍｇ／Ｌ，（１４７．８５±３６．２６）％，Ｐ值均小于０．０１］，且二者之间呈明显正相关（ｒ＝０．４３９，Ｐ＜０．０２）．②初发非霍奇金淋巴瘤（ＮＨＬ）患者血浆ＶＷＦ含量（２５４．２８±４４．７３）％明显高于霍奇金病（ＨＤ）组（１４６．７９±７０．５１）％和ＮＨＬ缓解组（１４９．２５±４３．９２）％，Ｐ＜０．０１，ＨＤ则无此变化．结论：①初发ＭＬ患者存在不同程度的高凝状态．②血浆ＶＷＦ含量变化对ＮＨＬ的诊断和预后有一定的参考价值．
Objective: To investigate the clinical significance of plasma D-dimer (DD) and von Willebrand factor (VWF) levels in patients with malignant lymphoma (ML). Methods: Plasma DD and VWF levels were detected in 52 patients with ML by ELISA double antibody sandwich method. Results: 1 The plasma levels of DD and VWF in the patients with primary ML were significantly higher than those in the controls [(0.1734±0.1194) mg/L, (204.12±78.81)%] [(0.1030±0. 0291) mg/L, (147.85±36.26)%, P value less than 0.01], and there was a significant positive correlation between them (r=0.439, P<0.02). 2 The plasma VWF content (254.28±44.73)% was significantly higher in primary non-Hodgkin lymphoma (NHL) patients than in Hodgkin’s disease (HD) group (146.79±70.51)% and NHL relief. Group (149.25±43.92)%, P<0.01, HD did not have this change. Conclusion: 1 There are different degrees of hypercoagulability in patients with primary ML. 2. The change of plasma VWF content has certain reference value for the diagnosis and prognosis of NHL.