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目的探讨类风湿性关节炎患者早期肾功能损害的相关因素。方法选择30例住院的类风湿性关节炎患者为观察组,38例健康体检者为正常对照组,分别检测观察组及正常对照组的血清胱抑素C(CysC)、尿素氮(BUN)、血肌酐(Scr)。结果观察组血清CysC水平明显高于正常对照组,差异有统计学意义(P<0.05);而BUN、Scr与正常对照组比较差异无统计学意义(P>0.05)。结论测定CysC对于类风湿性关节炎早期肾损害的诊断和治疗有着重要的临床意义。
Objective To investigate the related factors of early renal dysfunction in patients with rheumatoid arthritis. Methods Thirty patients with rheumatoid arthritis were selected as observation group and 38 healthy controls as normal control group. Serum levels of cystatin C (CysC), blood urea nitrogen (BUN) Serum creatinine (Scr). Results The level of serum CysC in the observation group was significantly higher than that in the normal control group (P <0.05). There was no significant difference between the BUN and Scr in the observation group and the normal control group (P> 0.05). Conclusion The determination of CysC has important clinical significance for the diagnosis and treatment of early renal damage in rheumatoid arthritis.