Preparation and quality evaluation of vincristine sulfate-loaded PEG-PLGA nanoparticles

• 作 者: Ting-ting Guo Hong-yuan Zhu We
• 机 构: SchoolofPharmacy,MerckSharp&,DohmePharmaceuticals
• 出 处: 中国现代医学杂志
• 发表日期: 2011年6期
• 基金项目: Acknowledgements Thanks to the National 863 Hi-tech Project for financial support （2007AA021803, 2007AA021901 ）.

Objective To prepare the PEG-PLGA nanoparticles loaded with vincristine sulfate(VCR-loaded PEG-PLGA-NPs) and evaluate their quality.Methods VCR-loaded PEG-PLGA-NPs were prepared by the double emulsion solvent evaporation method.The main experimental facto