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有机磷农药(organophosphorus pesticides,OPs)产生的毒性除了全身毒性症状外,还具有神经发育毒性,胚胎期和出生后有机磷农药暴露能对快速生长发育中的胎儿和婴幼儿健康造成潜在的危害,并可能持续存在,在短期或远期内诱发某些神经精神类疾病。除胆碱酯酶抑制途径外,其他非胆碱酯酶途径也参与了其神经发育毒性作用,虽然具体机制还未明确,但已发现涉及细胞信号途径。
Organophosphorus pesticides (OPs) produce toxicity in addition to systemic toxicity symptoms, but also have neurodevelopmental toxicity, embryonic and postnatal exposure to organophosphorus pesticides on the fast-growing fetuses and infants and young children potential health hazards, And may persist in the short term or long term induced certain neuropsychiatric diseases. In addition to the cholinesterase inhibition pathway, other non-cholinesterase pathways are also involved in their neurodevelopmental toxic effects. Although the exact mechanism remains unclear, it has been found that cellular signaling pathways are involved.