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本文对97例不育男子及13例证实有生育能力男子精浆中的九种微量元素(锌、铁、锰、铜、镍、钾、纳、钙和镁)的浓度用原子吸收分光光度法进行了测定。结果表明:钾、钠和钙在不育与正常男子精浆中的水平几乎一样。不育症患者精浆中的铁、锰和铜浓度高于正常生育力男子精浆中的浓度,其中铁(P<0.05)和锰(P<0.01)的差异具有统计学意义。镍的浓度(P<0.05)显著低于正常男子。具有正常精子密度的不育患者精浆中铁(P<0.05)和锰(P<0.01)显著高于正常男子,锌和铜的浓度也高于正常男子,但无统计学意义。无精患者精浆中的镁(P<0.01)、镍(P<0.05)和铁(P<0.05)浓度明显低于正常男子。镁和镍在不育患者精浆中的浓度随精子密度降低而逐渐降低,但无统计学意义。经迴归处理实验数据,结果表明,锌—钾,锌—钙,锌—镁;钙—钾,钙—镁和镁—钾无论在正常组还是不育组均存在明显的正相关。作者认为结合反映前列腺功能的其他生化指标来测定精浆中的铁、锰、镍及镁的水平有利于对不育症的诊断。
The concentrations of nine trace elements (zinc, iron, manganese, copper, nickel, potassium, sodium, calcium and magnesium) in 97 infertile men and 13 fertile men who were fertile were determined by atomic absorption spectrophotometry The measurement was carried out. The results show that: potassium, sodium and calcium levels in infertility and normal men’s seminal plasma is almost the same. The concentrations of iron, manganese and copper in the seminal plasma of infertile patients were higher than those in normal fertility men’s seminal plasma, and the difference between iron (P <0.05) and manganese (P <0.01) was statistically significant. The nickel concentration (P <0.05) was significantly lower than that of normal men. Iron (P <0.05) and manganese (P <0.01) in seminal plasma of patients with normal sperm density were significantly higher than those of normal men, and the concentrations of zinc and copper were also higher than those of normal men, but there was no statistical significance. Magnesium (P <0.01), nickel (P <0.05) and iron (P <0.05) concentrations in seminal plasma of patients with azoospermia were significantly lower than those of normal men. The concentration of magnesium and nickel in the seminal plasma of infertile patients gradually decreased with the decrease of sperm density, but there was no statistical significance. The results of regression analysis showed that there was a significant positive correlation between zinc - potassium, zinc - calcium, zinc - magnesium, calcium - potassium, calcium - magnesium and magnesium - potassium in both normal and infertile groups. The authors conclude that determining the levels of iron, manganese, nickel and magnesium in seminal plasma in combination with other biochemical markers that reflect prostate function is good for the diagnosis of infertility.