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目的:探讨妊娠妇女血清视黄醇结合蛋白和C反应蛋白早期预测妊娠期糖尿病的价值。方法:采用病例对照研究,检测并比较88例妊娠期糖尿病及88例正常妊娠妇女孕16~20周血清视黄醇结合蛋白和C反应蛋白浓度水平。结果:妊娠期糖尿病组孕妇血清视黄醇结合蛋白和C反应蛋白浓度均高于对照组,差异有统计学意义(P<0.05),血清视黄醇结合蛋白和C反应蛋白水平呈正相关(P<0.05)。血清视黄醇结合蛋白≥30.45 mg/L时预测妊娠期糖尿病的敏感性为63.6%,特异性为75.0%;血清C反应蛋白≥3.25 mg/L时预测妊娠期糖尿病的敏感性为56.8%,特异性为68.2%。结论:孕16~20周孕妇血清视黄醇结合蛋白水平对于妊娠期糖尿病的预测价值高于血清C反应蛋白。
Objective: To investigate the value of serum retinol binding protein and C-reactive protein in predicting gestational diabetes mellitus in pregnant women. Methods: A case-control study was conducted to detect and compare serum retinol binding protein and C-reactive protein levels in 88 pregnant women with gestational diabetes mellitus and 88 normal pregnant women at 16-20 weeks’ gestation. Results: Serum retinol binding protein and C-reactive protein levels in pregnant women with gestational diabetes mellitus were significantly higher than those in control group (P <0.05), serum retinol binding protein and C-reactive protein were positively correlated (P <0.05). The sensitivity and specificity of predicting gestational diabetes mellitus were 63.6% and 75.0% respectively when serum retinol binding protein was ≥30.45 mg / L; the sensitivity of predicting gestational diabetes mellitus with serum C-reactive protein ≥3.25 mg / L was 56.8% Specificity was 68.2%. Conclusion: The predictive value of serum retinol binding protein in pregnant women with gestational diabetes from 16 to 20 weeks pregnant is higher than that of serum C-reactive protein.