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目的:观察米非司酮配合桂枝茯苓胶囊治疗围绝经期子宫肌瘤的疗效。方法:36例患者随机分为2组各18例,对照组每月经潮后第5天起口服米非司酮治疗,每次12.5 mg,每天1次,至下次经潮前停服。30天为1疗程,治疗1疗程后未绝经或肌瘤缩小不明显者再重复下一疗程治疗,连续治疗3疗程;观察组在对照组治疗的基础上口服桂枝茯苓胶囊治疗,疗程同对照组。结果:治疗3~6月后,2组患者子宫及肌瘤体积均有缩小变化,但观察组缩小更为明显,2组治疗后比较,差异均有显著性意义(P<0.05)。显效率和总有效率观察组分别为50.0%、94.4%;对照组分别为38.9%、83.3%。2组显效率和总有效率比较,差异均有显著性意义(P<0.05)。结论:米非司酮配合桂枝茯苓胶囊治疗围绝经期子宫肌瘤,可以缩小肌瘤体积,纠正贫血,促其绝经,术前用药利于手术,且不良反应发生率低。
Objective: To observe the curative effect of mifepristone and Guizhi Fuling Capsule on perimenopausal uterine fibroids. Methods: Thirty-six patients were randomly divided into two groups of 18 cases. The control group took mifepristone once a day from the fifth day after tide, each time 12.5 mg once daily until the next time before taking tide. 30 days for a course of treatment, after 1 course of treatment did not menopause or fibroids were not significantly reduced and then repeat the next course of treatment, continuous treatment of 3 courses; observation group in the control group on the basis of oral Guizhi Fuling capsule treatment, treatment with the control group. Results: After 3 to 6 months of treatment, the volume of uterus and fibroids decreased in both groups, but the reduction in observation group was more obvious. There was significant difference between the two groups after treatment (P <0.05). Significant efficiency and total efficiency of the observation group were 50.0%, 94.4%; control group were 38.9%, 83.3%. There was significant difference between the two groups in apparent efficiency and total effective rate (P <0.05). Conclusion: Mifepristone combined with Guizhi Fuling Capsule in the treatment of perimenopausal uterine fibroids can reduce fibroid volume, correct anemia, and promote menopause, preoperative medication conducive to surgery, and the incidence of adverse reactions is low.