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目的:探讨重组牛碱性成纤维细胞生长因子滴眼液(bFGF)治疗外伤性角膜上皮缺损的临床效果和安全性。方法:将2007年1月-2008年7月在我院就诊的100例(100眼)外伤性角膜上皮缺损患者随机分成治疗组50例和对照组50例,治疗组给予bFGF滴眼,qid,每次1～2滴;对照组给予玻璃酸钠滴眼液(爱丽滴眼液)点眼,qid,每次1～2滴。并根据病情给予清创缝合、抗炎及对症处理,观察滴眼后2,4d角膜上皮缺损修复情况。结果:滴眼后2d和4d,bFGF治疗组外伤性角膜上皮缺损的治愈率均明显高于对照组,经χ2检验,治疗组与对照组在滴眼后2,4d差异均有极显著性(P<0.01)。结论:bFGF能很好地促进角膜上皮再生和修复,缩短病程,是一种治疗外伤性角膜上皮缺损的有效方法。
Objective: To investigate the clinical effect and safety of recombinant bovine basic fibroblast growth factor eye drops (bFGF) in the treatment of traumatic corneal epithelial defects. Methods: 100 cases (100 eyes) of traumatic corneal epithelial defect treated in our hospital from January 2007 to July 2008 were randomly divided into treatment group (50 cases) and control group (50 cases). The treatment group was given bFGF eye drop, qid, Each 1 to 2 drops; control group given sodium hyaluronate eye drops (Aili eye drops) eye, qid, each 1 to 2 drops. According to the disease, debridement, anti-inflammatory and symptomatic treatment were given to observe the situation of corneal epithelial defect repair after 2-hour drip. Results: The cure rates of traumatic corneal epithelial defect in bFGF treatment group were significantly higher than those in control group 2 and 4 days after the instillation. There was significant difference between the treatment group and the control group 2 and 4 days after the instillation P <0.01). Conclusion: bFGF can well promote the regeneration and repair of corneal epithelium, and shorten the course of the disease. It is an effective method to treat traumatic corneal epithelial defects.