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目的:研究分析临床低危型前列腺根治性切除术后病理升级的危险因素。方法:选取我院收治的60例行根治性前列腺切除术的前列腺癌患者,对患者的临床资料进行回顾分析。结果:60例大体病理与穿刺病理Gleason评分相比,其结果显示,大体病理与术前穿刺病理Gleason评分均在≤6分的患者36例(60.0%),较术前穿刺病理升级者有24例(40.0%),其中4+3分有7例(11.67%),3+4分有13例(21.67%),8分的有2例(3.33%),9分的有2例(3.33%)。在穿刺前PAS以及前列腺体积具有显著性差异(P<0.05),经统计学分析,具有统计学意义。进入Logistic多因素回归分析,其结果显示,前列腺体积小是前列腺根治术后病理升级的独立危险因素。经过不同前列腺体积分层对术后病理升级危险因素显示,较小体积组及中等体积组的前列腺是较大体积前列腺肿瘤患者发生病理升级的3.70倍及2.20倍。结论:较小体积的前列腺是前列腺癌性根治性切除术后发生病理升级的独立危险因素,在临床的治疗中应给与高度重视。
Objective: To study and analyze the risk factors of pathological upgrade after radical prostatectomy in clinical low-risk type. Methods: A total of 60 patients with prostate cancer undergoing radical prostatectomy were enrolled in our hospital. The clinical data of the patients were retrospectively analyzed. Results: Compared with pathological Gleason score of 60 cases, the results showed that there were 36 cases (60.0%) with pathological Gleason score less than 6 in both gross pathology and preoperative puncture pathology, compared with 24 There were 7 cases (11.67%) in 4 + 3 points, 13 cases (21.67%) in 3 + 4 points, 2 cases (3.33%) in 8 points and 2 cases (3.33 %). There were significant differences in PAS and prostate volume before puncture (P <0.05), which was statistically significant. Into the Logistic multivariate regression analysis, the results show that prostate small size is an independent risk factor for pathological upgrade after radical prostatectomy. After different prostate volume stratification on the postoperative pathological risk factors, the smaller volume group and the middle volume group of prostate is larger than the volume of prostate cancer patients pathological upgrade 3.70 times and 2.20 times. Conclusion: The smaller volume of prostate is an independent risk factor for pathological upgrade after radical prostatectomy, which should be given great attention in the clinical treatment.