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目的探讨使用蛋白分解酶阻制剂及抗生素区域动脉灌注对重症急性胰腺炎的疗效。方法19例重症急性胰腺炎患者行经股动脉穿刺置管,经腹腔动脉等注入萘莫司他和泰能,连续灌注2~7d。结果死亡4例,死亡率21.1%,有效15例,有效率78.9%。灌注治疗后,胰腺的改变12例正常,6例形成假性囊肿,并逐渐缩小,1例非感染性坏死。导管无闭塞、感染、血栓形成。有效率78.9%。结论此疗法死亡率无明显改善,但抗感染有效。
Objective To investigate the effect of protease inhibitors and antibiotic regional arterial infusion on severe acute pancreatitis. Methods Nineteen patients with severe acute pancreatitis underwent catheterization through the femoral artery and perfused with nafasumab and tacrolimus via celiac artery for 2 ~ 7 days. Results of death in 4 cases, the mortality rate of 21.1%, effective in 15 cases, the effective rate of 78.9%. After perfusion treatment, 12 cases of normal pancreatic changes, 6 cases of pseudocyst formation, and gradually reduced, 1 case of non-infectious necrosis. Catheter occlusion, infection, thrombosis. Effective rate of 78.9%. Conclusion There is no significant improvement in the mortality of this therapy, but anti-infection is effective.