论文部分内容阅读
目的探讨煤工尘肺伴慢性阻塞性肺疾病(COPD)患者早期肾功能损害变化及临床意义。方法采用免疫透射比浊法和速率法,测定煤工尘肺伴COPD和煤工尘肺伴COPD同时合并慢性呼吸衰竭患者,晨尿中视黄醇结合蛋白(RBP)、微量白蛋白(mAlb)含量和N-乙酰-β氨基葡萄糖苷酶(NAG)活力。结果煤工尘肺伴COPD时,3项肾功能早期损伤指标中,只有尿RBP(0.38±0.06 mg/L)水平与对照组(0.18±0.06 mg/L)比较,差异有统计学意义(P<0.01),而在煤工尘肺伴COPD同时合并慢性呼吸衰竭时,患者尿RBP(1.12±0.18 mg/L)、mAlb(47.5±10.52 mg/L)和NAG(28.00±8.51U/L)3项指标均明显升高,与对照组比较,差异均有统计学意义(P<0.01)。结论煤工尘肺伴COPD时,及时测定肾功能早期损伤的生化指标尿RBP、mAlb和NAG可早期发现肾功能损害。
Objective To investigate the changes and clinical significance of early renal dysfunction in coal worker’s pneumoconiosis with chronic obstructive pulmonary disease (COPD). Methods Immunoturbidimetric method and rate method were used to determine the content of RBP, mAlb and Nl in patients with COPD and coal worker’s pneumoconiosis with COPD combined with chronic respiratory failure. - Acetyl-β-glucosaminidase (NAG) activity. Results In coal workers’ pneumoconiosis with COPD, only the urinary RBP (0.38 ± 0.06 mg / L) was significantly higher than that of the control group (0.18 ± 0.06 mg / L) in the three indicators of early renal injury (P < 0.01), while RBP (1.12 ± 0.18 mg / L), mAb (47.5 ± 10.52 mg / L) and NAG (28.00 ± 8.51U / L) were the most common risk factors for COPD with COPD Indicators were significantly increased, compared with the control group, the difference was statistically significant (P <0.01). Conclusions In coal worker pneumoconiosis with COPD, renal biologic impairment, such as urinary RBP, mAlb and NAG, can be detected in time.