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比较青霉胺及锌剂治疗肝豆状核变性（ＨＬＤ）的疗效及对尿铜排泄的作用。用阳极溶出伏安法（ＡＳＶ法）测定患者的 ２４ ｈ尿铜排泄量，资料分析采用 Ｘ２检验及 ｔ检验。结果： ６９例用青霉胺及锌剂治疗的 ＨＬＤ患者，青霉胺治疗组疗程为 １０．２５± ３．８４ ａ，有效率为 ９４．２％。锌剂治疗组疗程为 ３．６２± ０．９４ ａ，有效率为 ５８．８％。治疗同期的尿铜排泄量青霉胺组明显高于锌剂组（Ｐ＜０．０１）。结论：青霉胺疗效明显优于锌剂，青霉胺较锌剂更能有效地驱除造成组织损害的体内已蓄积的过量游离铜。
To compare the curative effect of penicillamine and zinc on hepatolenticular degeneration (HLD) and its effect on urinary copper excretion. The 24 h urinary copper excretion was measured by anodic stripping voltammetry (ASV). Data analysis was performed by X2 test and t test. Results: In 69 cases of HLD patients treated with penicillamine and zinc, the treatment course of penicillamine was 10.25 ± 3.84 a and the effective rate was 94.2%. The treatment of zinc treatment group was 3.62 ± 0.94 a, the effective rate was 58.8%. Urinary copper excretion during the same period of treatment with penicillamine was significantly higher than zinc (P <0.01). CONCLUSION: Penicillamine is superior to zinc agent in efficacy, and penicillamine is more effective than zinc agent in removing excess free copper accumulated in the body that causes tissue damage.