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The use of Chinese medicinal herbs (CMH) continues to expand rapidly across the world with a deep belief that herbs are safe because they are “natural”.(1) However,a survey of the literature indicates that CMH related hepatotoxicity is increasing and has been a worldwide problem.(2,3) Polygonum multiflorum Thunb.(P.multiflorum),officially listed in the Pharmacopoeia of the People\'s Republic of China,(4) has been used effectively for thousands of years in China as a popular herb to prevention aging and hair graying and it is generally regarded as non-toxic.