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目前上市的治疗关节炎的非甾类抗炎药(NSAID)有阻断环氧合酶-1(COX-1)和COX-2的作用。而COX-1能保护胃粘膜却在炎症方面不起多大作用,只有COX-2似能特异地涉及造成炎症的物质环前列腺素的产生。故COX-2抑制剂的出现是关节炎治疗中的一个进展。在1997年美国风湿病学学会的会议上
Currently available non-steroidal anti-inflammatory drugs (NSAIDs) for the treatment of arthritis block the effects of cyclooxygenase-1 (COX-1) and COX-2. While COX-1 can protect the gastric mucosa but does not play much role in the inflammation, only COX-2 can specifically be involved in the production of inflammation of the material prostaglandins. Therefore, the emergence of COX-2 inhibitors is an advance in the treatment of arthritis. At the 1997 meeting of the American College of Rheumatology