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细胞膜存在雌激素受体的非基因组效应。 17β-雌二醇〔E2 〕胞膜受体 ,通过增加Ca2 + 内流和环核苷酸途径诱导快速信号转导过程 ,如磷酸肌醇 3-激酶系统、蛋白激酶B/AKT系统、ERK和P38MAP激酶系统转导通路。这些通路使E2 膜效应与细胞其他功能紧密衔接 ;E2 非基因组效应参与神经和血管细胞调节作用。E2 受体池假说很好地解释E2 基因组和非基因组效应的协调性和统一性
Non-genomic effects of estrogen receptors exist on the cell membrane. The 17β-estradiol (E2) cell membrane receptor induces rapid signal transduction processes such as the phosphoinositide 3-kinase system, the protein kinase B / AKT system, the ERK and the ERK by increasing the Ca 2+ influx and the cyclic nucleotide pathway P38MAP kinase system transduction pathway. These pathways make the E2 membrane effect and other cell functions closely linked; E2 non-genomic effects in nerve and vascular cell regulation. E2 Receptor Pool Hypothesis Well Explains the Coordination and Uniformity of the E2 Genomic and Nongenomic Effects