论文部分内容阅读
抗肿瘤药顺铂有引起恶心、呕吐的副反应。作者对37例接受顺铂治疗者肌注促皮质素(ACTH)进行了止吐实验。患者中卵巢癌28例,结—直肠癌4例,睾丸癌3例,软组织肉瘤2例。所有患者均按双盲法进行ACTH和安慰剂对照。每次肌内注射ACTH1ml,内含1mgACTH;安慰剂1 ml,内只有溶剂。ACTH和安慰剂24小时内各肌注2次,静点顺铂前再各肌注一次。此外,所有患者在静点顺铂前,均肌注氯丙嗪50mg。观察与评定时间为24小时。实验结果表明,ACTH组比安慰剂组呕吐持继时间缩短近2.5倍,呕吐次数ACTH组与安慰剂组之比为30:112。作者认为,肌注ACTH对接受顺铂治疗者的止吐
Cisplatin antineoplastic drug can cause nausea and vomiting. The authors performed an anti-emetic experiment on 37 patients with cisplatin-treated intramuscular corticotropin (ACTH). Ovarian cancer in patients with 28 cases, 4 cases of colorectal cancer, testicular cancer in 3 cases, 2 cases of soft tissue sarcoma. All patients were double-blind ACTH and placebo-controlled. Each intramuscular injection of ACTH1ml, containing 1mgACTH; placebo 1ml, only the solvent. ACTH and placebo intramuscular injection within 24 hours 2 times, intravenous cisplatin each intravenous injection once. In addition, all patients were primed with chlorpromazine 50 mg before cisplatin. Observation and assessment of time for 24 hours. Experimental results show that ACTH group than in the placebo vomiting shortened nearly 2.5 times the vomiting ACTH group and placebo group ratio of 30: 112. The authors believe that intramuscular ACTH on cisplatin treatment of patients receiving antiemetic