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目的探讨妊娠合并甲状腺功能亢进症(甲亢)对孕妇妊娠结局及围生儿的影响。方法 58例妊娠合并甲状腺功能亢进症的孕妇,根据病情的控制情况分为控制组(32例)和未控制组(26例),并将同期孕检的正常妊娠初产妇28例作为对照组。通过测定三组孕妇血清β_2-微球蛋白(β_2-MG)和甲状腺功能(甲功)3项[游离三碘甲腺原氨酸(FT_3)、游离甲状腺素(FT_4)、促甲状腺激素(TSH)],分析妊娠合并甲状腺功能亢进症孕妇的妊娠结局。结果三组孕妇的β_2-MG、FT_3、FT_4、TSH的血清检测值比较,差异均具有统计学意义(P<0.05);其中控制组血清β_2-MG、FT_3、FT_4检测值低于未控制组,TSH检测值高于未控制组(P<0.05);未控制组血清β_2-MG、FT_3、FT_4检测值高于对照组,TSH检测值低于对照组(P<0.05)。未控制组早产、引产、流产、甲亢性心脏病、妊娠期高血压病的发生率均明显高于控制组和对照组(P<0.05)。结论妊娠合并甲亢的孕妇积极地控制甲状腺激素的水平,可以有效地减少不良妊娠的发生。
Objective To investigate the effect of pregnancy complicated with hyperthyroidism (Hyperthyroidism) on pregnancy outcomes and perinatal children. Methods Fifty-eight pregnant women with pregnancy complicated with hyperthyroidism were divided into control group (n = 32) and uncontrolled group (n = 26) according to the condition control. Twenty-eight normal pregnant primiparae in the same period were used as the control group. The serum levels of β_2-microglobulin (β_2-MG) and thyroid function (thyroid function) were measured in three groups of pregnant women [free triiodothyronine (FT_3), free thyroxine (FT_4), thyrotropin )], Analyze the pregnancy outcome of pregnant women with hyperthyroidism. Results The serum levels of β_2-MG, FT_3, FT_4 and TSH in the three groups of pregnant women were significantly lower than those in the control group (P <0.05). The serum levels of β_2-MG, FT_3 and FT_4 in the control group were lower than those in the control group (P <0.05). The detection values of serum β_2-MG, FT_3 and FT_4 in the non-control group were higher than those in the control group, and the detection values of TSH were lower than those in the control group (P <0.05). The incidence of preterm labor, induced abortion, abortion, hyperthyroidism heart disease and gestational hypertension in the control group were significantly higher than those in control group and control group (P <0.05). Conclusion Pregnant women with hyperthyroidism in pregnancy actively control thyroid hormone levels, which can effectively reduce the incidence of adverse pregnancy.