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目的探讨老年高血压患者脉压(PP)与血清超敏C-反应蛋白(Hs-CRP)的相关性。方法选择160例老年原发性高血压(EH)患者,测定其血清Hs-CRP、总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白(HDL-C)、低密度脂蛋白(LDL-C)及血糖(FBG)等生化指标,按PP高低分为<60 mmHg、60~80 mmHg、80~100 mmHg和>100 mmHg 4组,比较各组间Hs-CRP水平。结果随着PP逐渐升高,血清Hs-CRP水平亦渐见上升,各组间比较差异有统计学意义(P<0.05)。结论老年高血压患者高PP与CRP存在着正相关,提示炎症反应与PP升高共同存在。
Objective To investigate the correlation between pulse pressure (PP) and serum high sensitive C-reactive protein (Hs-CRP) in elderly patients with hypertension. Methods A total of 160 elderly patients with essential hypertension (EH) were enrolled in this study. Serum levels of Hs-CRP, TC, TG, HDL-C, LDL-C) and blood glucose (FBG). The levels of Hs-CRP in each group were compared between 4 groups according to the level of PP: <60 mmHg, 60-80 mmHg, 80-100 mmHg and> 100 mmHg. Results With the gradual increase of PP, the serum Hs-CRP level also gradually increased, with significant difference between the groups (P <0.05). Conclusion There is a positive correlation between high PP and CRP in elderly patients with hypertension, suggesting that inflammatory reaction coexists with elevated PP.