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本文仅就几种重要的药物简介如下。一、L-多巴:1.L-多巴治疗本病的机理:本世纪五十年代后期及六十年代初期有人发现震颤麻痹患者的纹状体中多巴胺(DA)含量显著减少。动物实验若破坏黑质细胞体或黑质纹状体通路,可引起同侧纹状体的DA丧失。这些发现说明DA是由黑质制造后,经黑质纹状体通路运输至纹状体,并贮藏于纹状体的神经末梢小泡中。现已肯定脑中DA的减少是震颤麻痹发生的原因,且震颤麻痹的病变主要在黑质和黑质纹状体通路,至晚期纹状体亦可变性。六十年代初期还有人提出纹状体中存在两
This article only on several important drugs are as follows. First, L-dopa: 1. L-dopa treatment of the mechanism of the disease: the late fifties of this century and early sixties was found in patients with Parkinson’s disease striatum dopamine (DA) content was significantly reduced. Animal experiments if the destruction of nigral cell body or nigrostriatal pathway, can cause ipsilateral striatal DA loss. These findings suggest that DA is produced by the substantia nigra and transported via the nigrostriatal pathway to the striatum and is stored in the striatum in the nerve terminal vesicles. It has been affirmed that the reduction of brain DA is the cause of paralysis, and the pathology of paralysis of paralysis mainly in the substantia nigra and nigrostriatal pathways, to the late striatum can also be denatured. It was also suggested in the early 1960s that two exist in the striatum