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一氧化氮是一种不稳定的低分子有害气体 ,同时它又是一种生物活性物质 ,参与了多种疾病的病理生理过程。一氧化氮在体内由L 精氨酸在一氧化氮合成酶的作用下生成 ,作为一种非肾上腺能非胆碱能神经递质 ,对动物和人的生殖泌尿器官平滑肌张力起着重要的调节作用。本文简要介绍一氧化氮在体内的产生机制和分布 ,并着重概述一氧化氮对平滑肌舒张调节作用机理 ,及其在非手术治疗前列腺增生导致下尿路梗阻及改善阴茎勃起功能障碍方面的临床应用。
Nitric oxide is an unstable, low molecular harmful gas, and at the same time, it is a bioactive substance involved in the pathophysiological process of many diseases. Nitric oxide is produced by L-arginine in the body under the action of nitric oxide synthase. As a non-adrenergic non-cholinergic neurotransmitter, nitric oxide plays an important regulatory role in the tone of genito-urinary organs in animals and humans effect. This article briefly introduces the mechanism and distribution of nitric oxide in the body and focuses on the mechanism of nitric oxide on the relaxation of smooth muscle and its clinical application in non-surgical treatment of lower urinary tract obstruction of benign prostatic hyperplasia and improvement of erectile dysfunction .