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半导体量子点(或称半导体纳米微晶体)与传统的有机荧光标记物相比,具有独特的光谱特性和良好的光化学稳定性。近年来随着水溶性量子点制备技术、纳米技术和生物技术的飞速发展,基于半导体量子点发展起来的生物亲和性功能化的纳米荧光探针,提供了对体内活细胞或活细胞内多种生物分子“编码”标记后同时进行多通道原位实时动态研究的技术平台。现综述半导体量子点荧光探针的光谱特性及其在活细胞生理条件下用于恶性肿瘤的研究进展和发展前景
Semiconductor quantum dots (or semiconductor nanocrystals) have unique spectral properties and good photochemical stability compared to traditional organic fluorescent labels. In recent years, with the rapid development of water-soluble quantum dot preparation technology, nanotechnology and biotechnology, biologically-compatible functionalized nanofluorescence probes based on semiconductor quantum dots have provided a method for the in vivo living cells or living cells Kind of biomolecule “coding” tag at the same time multi-channel real-time dynamic state of the technology platform. Now reviewing the spectral characteristics of semiconductor quantum dot fluorescence probes and their research progress and prospects for malignant tumors under living cell physiological conditions