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目的:观察苦参素与琢-2b干扰素治疗慢性乙肝的临床疗效。方法:对75例慢性乙肝患者随机分为苦参素治疗组与琢-2b治疗组,用ELISA法检测HBeAg,用PCR法检测HBV-DNA,观察2组中HBeAg、HBV-DNA阴转情况。结果:苦参素组总有效率为17/42(40.72%),琢-2b干扰素组总有效率为15/31(45.45%),两者统计学处理无显著差异(P>0.05);结论:苦参素注射液近期疗效肯定,为一种治疗慢性乙肝的可选药。
Objective: To observe the clinical efficacy of oxymatrine and nicotinamide-2b in treatment of chronic hepatitis B. Methods: Seventy-five patients with chronic hepatitis B were randomly divided into the oxymatrine treatment group and the Zhuo-2b treatment group. HBeAg was detected by ELISA, HBV-DNA was detected by PCR, and the negative conversion of HBeAg and HBV-DNA in two groups was observed. Results: The total effective rate was 17/42 (40.72%) in the oxymatrine group and 15/31 (45.45%) in the bisabolene interferon group. There was no significant difference between the two groups (P> 0.05). Conclusion: The recent efficacy of oxymatrine injection for the treatment of chronic hepatitis B is an optional drug.