论文部分内容阅读
虽然自从十八世纪中叶Withering首次报道以来,洋地黄糖甙的应用极为广泛,但它仍然是一组极难使用的药物。甚至在今天,对其临床药理学有了很多的了解之后,其中毒的发生率仍然很高。波士顿市医院曾统计931例连续住院病例,931例中135例用洋地黄治疗,其中28.9％出现毒性表现。在这一组病人中,未服用洋地黄者的死亡率为8％,服用洋地黄而无毒性表现者为16％,而心电图示有毒性表现者则接近40％。当然,后者
Although the application of digitalis has been extremely widespread since Withering first reported in the mid-18th century, it remains a group of extremely difficult drugs. Even today, a lot of understanding of its clinical pharmacology, the incidence of poisoning is still high. Boston Hospital has counted 931 consecutive hospitalizations and 135 of 931 patients treated with digitalis, with 28.9% of them having toxic manifestations. In this group of patients, those who did not take digitalis had a mortality rate of 8%, those who took digitalis with no toxicity showed 16%, and those who showed electrocardiogram (ECG) toxicity were close to 40%. Of course, the latter