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对12例14个患者有慢性根尖周炎伴根尖周肉芽肿形成的患牙进行根尖切除术和根尖肉芽肿刮治术。将切除的根尖和刮除的根尖周肉芽组织经处理后进行扫描电子显微镜观察,发现根尖孔内、外及根尖周肉芽组织内有大量的成堆的球菌。并发现有大量的炎性细胞浸润,炎性细胞以淋巴细胞主要是T淋巴细胞为主,有少量的巨噬细胞存在,说明根尖周肉芽肿的形成与根管内的感染有密切的关系。另外观察到根尖牙骨质的吸收以及上皮条索、纤维组织的存在推断牙周膜修复、上皮再附着的可能性
12 cases of 14 patients with chronic periapical periodontitis with periapical granuloma formation of the teeth were apical resection and apical granuloma cure. The resected apical and the periapical granulation tissue after treatment were observed by scanning electron microscopy, found within the apical foramen, outside and periapical granulation tissue in a large number of piles of bacteria. And found that there is a large number of inflammatory cell infiltration, inflammatory cells to lymphocytes, mainly T lymphocytes, a small amount of macrophages, indicating the formation of periapical granuloma and root canal infection are closely related . In addition, the absorption of apical cementum and the existence of epithelial cords and fibrous tissues were observed to infer the possibility of periodontal membrane repair and epithelial reattachment