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目的:探讨抗甲状腺自身抗体(antithyroid autoantibodies,ATA)阳性对体外受精-胚胎移植(invitrofertilizationandembryotransfer,IVF-ET)结局的影响。方法:回顾性分析行IVF/ICSI治疗不孕的患者资料。选取甲状腺抗体阳性但甲状腺功能正常者65例(共71个周期)作为研究组(ATA+组),492例甲状腺抗体阴性患者(共512个周期)作为对照组(ATA-组)。结果:ATA+组与ATA-患者的一般情况、促排卵天数、促性腺激素使用总量(Gn总量)、hCG注射日E2水平、获卵数、ICSI受精率、可移植胚胎数和妊娠率,组间比较均无统计学差异(P>0.05)。ATA+组IVF受精率(59.73%)、优质胚胎率(26.94%)明显低于ATA-组(70.86%和36.31%);ATA+组的流产率(37.50%)明显高于ATA-组(17.79%),差异有统计学意义(P<0.05)。结论:ATA+对IVF-ET妊娠结局有不利的影响,因此,对于ATA+患者在接受IVF-ET治疗前调节甲状腺自身免疫功能可对妊娠结局有利。
Objective: To investigate the effect of antithyroid autoantibodies (ATA) on the outcome of IVF-ET in vitro fertilization and embryo transfer (IVF-ET). Methods: Retrospective analysis of IVF / ICSI patients treated infertility data. Sixty-five patients (71 cycles) with positive thyroid antibody but normal thyroid function were selected as the study group (ATA + group) and 492 patients with thyroid negative antibody (512 cycles) as the control group (ATA-group). Results: The general situation, days of ovulation, total gonadotrophin use (total Gn), E2 level on hCG injection day, number of oocytes retrieved, ICSI fertilization rate, number of transferable embryos and pregnancy rate in ATA + group and ATA- There was no significant difference between the two groups (P> 0.05). IVF fertilization rate (59.73%) and high quality embryo rate (26.94%) in ATA + group were significantly lower than those in ATA group (70.86% and 36.31%). Abortion rate in ATA + group was significantly higher than that in ATA group (37.50% , The difference was statistically significant (P <0.05). CONCLUSIONS: ATA + has an adverse effect on IVF-ET pregnancy outcomes, and therefore, pregnancy outcomes may be beneficial for ATA + patients adjusting for thyroid autoimmune function prior to IVF-ET treatment.