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目的 :建立测定盐酸地尔硫艹卓 缓释片的含量测定方法。方法 :以乙醇为溶剂 ,以一阶导数光谱的谷 -零位值法测定盐酸地尔硫艹卓 的含量 ,测定波长λ谷 =2 50± 1nm。结果 :回收率 1 0 0 .0 1 % ,RSD 0 .3 8%～ 0 .4 7% ,线性范围2 .4～ 1 6.8μg/ml。 结论 :方法简便、快速、准确 ,适合于该制剂的含量测定。
Objective: To establish a method for the determination of diltiazem hydrochloride sustained release tablets. Methods: The content of diltiazem hydrochloride was determined by the valley - zero value method of first order derivative spectroscopy with ethanol as solvent. The wavelength λ = 250 ± 1 nm was determined. Results: The recovery was 100.0%, RSD 0.38% -0.47%, and the linear range was 2.4-1.8μg / ml. Conclusion: The method is simple, rapid and accurate and suitable for the determination of the content of the preparation.