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婴儿用硫喷妥钠诱导的需求量(mg/kg)比小儿大,1～6月婴儿有效剂量的中值为6.9mg/kg。但新生儿的需求量应该较小。为了阐明此问题作者选择期手术的0～14天新生儿10例和1～6月婴儿20例进行观察。此30例均属ASA Ⅰ～Ⅱ级,胎龄大于37周,出生时体重超过2500克。全部患儿的体温正常,无明显上呼吸道感染,非急症手术禁食4小时以上,不用术前药,入室后静注阿托品0.1mg,面罩吸O_2 1 min,静注2.5%硫喷妥钠3.2mg/kg,通过“增减法”取得ED_(50),即注射
Infant demand for thiopental sodium (mg / kg) than in children, 1 to 6 months the median effective dose of infants 6.9mg / kg. However, the demand for newborns should be smaller. In order to clarify this issue, the authors choose 10 cases of newborns from 0 to 14 days and 20 cases of infants from January to June in the selective operation. The 30 cases were ASA Ⅰ ~ Ⅱ grade, gestational age greater than 37 weeks, birth weight more than 2500 grams. All children with normal body temperature, no obvious upper respiratory tract infection, non-emergency surgery for more than 4 hours fasting, without preoperative medication, atropine 0.1mg after intraventricular infusion, mask inhalation O_2 1 min, 2.5% intravenous thiopental sodium 3.2 mg / kg, through the “increase and decrease method” to obtain ED_ (50), that is, injection