【摘 要】
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Porous functionalized silica nanoparticles have attracted the interest of researchers as they are excellent carriers for antibacterial drug delivery application
【机 构】
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Center for Smart Materials and Devices,State Key Laboratory of Advanced Technology for Materials Syn
论文部分内容阅读
Porous functionalized silica nanoparticles have attracted the interest of researchers as they are excellent carriers for antibacterial drug delivery applications.In this work,porous aminated-silica nanoparticles(SiO2-NH2 NPs) were prepared via one-step approach through the ammonia-catalyzed hydrolysis of tetraethylorthosilicate (TEOS) and (3-aminopropyl) triethoxysilane (APTES) in a mixed water-ethanol system.The obtained SiO2-NH2 NPs displayed a spherical morphology and relatively uniform size dis-tribution,while the morphology and structure of SiO2-NH2 NPs were mainly determined by the order of the reagents added and the pH value of the solution.After characterization,the results showed that there were a large number of-NH2 groups on the surface of porous SiO2-NH2 NPs and that the porous SiO2-NH2 NPs had a large surface area of 476 m2 g-1 with an average pore width of 4.3 nm.Through an absorbing-releasing experiment and bacterial test,those SiO2-NH2 NPs were found to exhibit efficient absorption and release of drugs as well as a pH-dependent release pattern of epirubicin-loaded SiO2-NH2 NPs.Meanwhile,SiO2-NH2@capsaicin NPs exhibited antibacterial properties.Those porous SiO2-NH2 NPs could be a candidate for drug delivery for antibacterial applications owing to their tailored porous structure and high surface area.
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