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目的:探讨蒙脱石散联合三联疗法治疗消化性溃疡的临床疗效及安全性。方法:研究对象为2015年11月-2016年12月我院的56例消化性溃疡病例,随机分为观察组及对照组,每组28例,对照组实施奥美拉唑、克拉霉素及阿莫西林三联治疗,观察组在此基础上给予蒙脱石散口服治疗,观察两组疗效及不良反应。结果:观察组治愈19例、显效8例、无效1例,总有效率为96.4%,对照组治愈6例、显效13例、无效9例,总有效率为67.8%,观察组总有效率显著高于对照组,其差异均有统计学意义(P<0.05);观察组恶心呕吐1例、头晕头痛1例、皮疹1例,总不良反应率为10.7%,对照组恶心呕吐3例、头晕头痛2例、皮疹1例,总不良反应率为21.4%,观察组不良反应率显著低于对照组,其差异均有统计学意义(P<0.05)。结论:蒙脱石散联合三联疗法治疗消化性溃疡疗效显著,安全可靠,值得临床上推广应用。
Objective: To investigate the clinical efficacy and safety of montmorillonite combined with triple therapy in the treatment of peptic ulcer. Methods: Fifty-six patients with peptic ulcer in our hospital from November 2015 to December 2016 were randomly divided into observation group and control group, with 28 cases in each group. Omeprazole, clarithromycin and Amoxicillin triple therapy, the observation group on the basis of montmorillonite given oral treatment, the two groups observed efficacy and adverse reactions. Results: In the observation group, 19 cases were cured, 8 cases were markedly effective, 1 case was ineffective, and the total effective rate was 96.4%. In the control group, 6 cases were cured, 13 cases were markedly effective, 9 cases were ineffective and the total effective rate was 67.8% (P <0.05). In the observation group, 1 patient had nausea and vomiting, 1 patient had dizziness and headache, 1 patient had skin rash and the total adverse reaction rate was 10.7%. The nausea and vomiting in the control group were 3 patients with dizziness There were 2 cases of headache and 1 case of rash. The total adverse reaction rate was 21.4%. The adverse reaction rate in the observation group was significantly lower than that in the control group (P <0.05). Conclusion: The combination of montmorillonite and triple therapy for peptic ulcer is effective, safe and reliable, which is worth popularizing and clinical application.