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作者概述了1973年Poldeman等发表的关于影响药物从栓剂中释放的因素,它包括直肠环境(如直肠液的量、组成、pH、缓冲容量、表面张力、粘度以及直肠腔的压力),药物(如溶解度、表面性质、颗粒大小、浓度和pK_a值)和赋形剂(如组成、熔融情况、表面张力和流变学性质);并用简图描述了栓剂药物释放的过程,包括熔融、铺展、转运、通过和溶出等五个阶段。在熔融方面,作者认为相变化由物理化学参数决定,这些参数包括赋形剂化学组成、
The authors outline the factors published in 1973 by Poldeman et al. For influencing the release of drugs from suppositories and include the rectal environment (eg, amount of rectal fluid, composition, pH, buffer capacity, surface tension, viscosity, and pressure in the rectum), drug Such as solubility, surface properties, particle size, concentration, and pK_a values) and excipients (such as composition, melting, surface tension and rheology); and a simplified diagram describing the process of suppository drug release including melting, spreading, Transport, through and dissolution of five stages. In terms of melting, the authors believe that phase changes are determined by physicochemical parameters, including the excipient chemical composition,