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目的:观察胱抑素C在小儿重症肺炎中的变化并探讨其临床意义。方法:选择重症肺炎患儿共60例,随机分为治疗组和对照组,治疗前均测定Cys-C和血肌酐(Scr),对照组采用吸氧吸痰、抗感染、止咳、化痰等治疗,治疗组在对照组基础上加用呋塞米,剂量为0.5～1mg/kg,治疗后观察Cys-C的变化,并就Cys-C的变化与Scr进行相关性分析。结果:治疗前两组在Cys-C和Scr增高相比无统计学意义(P>0.05),治疗期结束后,治疗组Cys-C全部恢复到正常,平均为0.81±0.25mg/L,与对照组相比,Cys-C变化具有显著的统计学意义(P<0.01),同时测定血清Cys-C与Scr之间进行相关性分析,结果显示呈高度相关性,r=0.87(P<0.05)。结论:小儿重症肺炎要重视对Cys-C的检测,有助于发现早期肾功能损伤并及时纠正,应用速尿可以改善肾功能,提高治愈率和缩短病程,具有很重要的临床应用价值。
Objective: To observe the changes of cystatin C in children with severe pneumonia and to explore its clinical significance. Methods: A total of 60 children with severe pneumonia were selected and randomly divided into treatment group and control group. Cys-C and serum creatinine (Scr) were measured before treatment. In the control group, oxygen inhalation, sputum, anti-cough and phlegm were used The treatment group and the treatment group were given furosemide at the dose of 0.5-1 mg / kg on the basis of the control group. The changes of Cys-C after treatment were observed. The correlation between Cys-C and Scr was analyzed. Results: There was no significant difference in Cys-C and Scr between the two groups before treatment (P> 0.05). After the treatment period, Cys-C in the treatment group returned to normal with an average of 0.81 ± 0.25 mg / L, Compared with control group, Cys-C had significant statistical significance (P <0.01). Correlation analysis between serum Cys-C and Scr showed a high correlation (r = 0.87, P <0.05 ). Conclusion: Severe pneumonia in children should pay attention to the detection of Cys-C, help to find early renal damage and promptly correct the application of furosemide can improve renal function, improve the cure rate and shorten the course of disease, has very important clinical value.