【摘 要】
：
目的 为进一步了解猪圆环病毒(Porcine circovirus,PCV)的遗传进化规律,为该病的预防和控制奠定基础.方法 对来自世界各国的26株PCV1和262株PCV2的全序列用生物软件进行了核
【机 构】
：
广西大学动物科技学院,南宁,530005
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目的 为进一步了解猪圆环病毒(Porcine circovirus,PCV)的遗传进化规律,为该病的预防和控制奠定基础.方法 对来自世界各国的26株PCV1和262株PCV2的全序列用生物软件进行了核苷酸的同源性比较,并对其ORF1和ORF2进行了核苷酸和推导氨基酸的比较.结果 从核苷酸水平来看,PCV1与PCV2明显分为两支,PCV1间分布没有规律,而PCV2间又分为以来自美国、加拿大、澳大利亚的序列为代表的亚型Ⅰ和以来自法国和新西兰的序列为代表的亚型Ⅱ;但从氨基酸水平来看,其分型并没有规律可循.从遗传进化树可以看出,PCV2的分布并没有地域性和时限性.数据统计显示,尽管相隔近十年之久,但其同源性并没有发生太大的改变,可见PCV2相当保守.另外对PCV2的碱基和氨基酸突变位点进行统计发现,PCV2序列间更倾向于碱基的颠换,但并无单个碱基和氨基酸的偏好性.结论 PCV2相对保守,地域性和时限性分布不明显.
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