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本研究旨在通过三氯醋酸对金黄地鼠颊囊粘膜作用的研究,了解其可能引起粘膜损伤的性质。为用于临床治疗提供理论依据。本试验是以金黄地鼠作为试验动物,20%三氯醋酸作为涂布试剂,手术后不同时期处死动物,对标本行光镜和透射电镜观察。结果显示:20%三氯醋酸可引起粘膜的坏死脱落,形成溃疡,坏死区由新生上皮替代,并且出现明显的纤维组织增生,提示:三氯醋酸用于口腔颌面部上皮性囊肿治疗,可能因上皮破坏治愈囊肿或降低其复发率。
The aim of this study was to investigate the mucosal effects of trichloroacetic acid on the cheek pouch of golden hamster, and to understand its possible mucosal damage. To provide a theoretical basis for clinical treatment. In this experiment, golden hamster was used as experimental animal and 20% trichloroacetic acid was used as coating reagent. Animals were sacrificed at different periods after operation. Specimens were observed under light and transmission electron microscopy. The results showed that: 20% trichloroacetic acid can cause mucosal necrosis, the formation of ulcers, the necrotic area replaced by new epithelial cells, and significant fibrosis, suggesting that: trichloroacetic acid for oral and maxillofacial cyst treatment may be Cures or reduces the recurrence rate due to epithelial disruption.