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目的探讨丙戊酸钠(VPA)对成人癫痫患者脂质代谢的影响。方法本试验为前瞻性研究,选择33例成人癫痫患者为试验组、36例健康人为对照组,分别检测试验组在VPA治疗前、治疗6mo后和对照组的血清总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白-胆固醇(LDL-C)、高密度脂蛋白-胆固醇(HDL-C)、致动脉粥样硬化率(TC/HDL-C和LDL-C/HDL-C)、体重指数(BMI),并进行比较。结果(1)试验组治疗前与对照组相比所有检测参数差异无显著意义(P>0.05),治疗6mo后TG、TC/HDL-C、LDL-C/HDL-C和BMI较对照组增高,HDL-C有减低趋势,差异有显著意义(P<0.05或P<0.01)。(2)试验组治疗前、后进行自身对照分析,治疗后TC、LDL-C、TC/HDL-C、LDL-C/HDL-C、BMI均较治疗前明显增高,HDL-C水平较治疗前下降,治疗前后比较差异有显著意义(P<0.05或P<0.01),而TG水平在治疗前后差异无显著意义(P>0.05)。(3)VPA治疗前后血脂谱和BMI的变化与各种危险因素(如年龄、性别、平均VPA剂量等)的相关性无显著意义(P>0.05)。结论VPA可导致成人癫痫患者脂质代谢异常和BMI增高。
Objective To investigate the effects of valproate (VPA) on lipid metabolism in adults with epilepsy. Methods This study was a prospective study. Twenty-three adult epilepsy patients were selected as the experimental group and 36 healthy controls as the control group. The levels of total cholesterol (TC), triacylglycerol TG, LDL-C, HDL-C, atherogenic rates (TC / HDL-C and LDL-C / HDL- , Body mass index (BMI), and compared. Results (1) There was no significant difference between the test group and the control group before treatment (P> 0.05). The levels of TG, TC / HDL-C, LDL-C / HDL- , HDL-C decreased trend, the difference was significant (P <0.05 or P <0.01). (2) The control group before and after treatment, TC, LDL-C, TC / HDL-C, LDL-C / HDL-C and BMI after treatment were significantly higher than before treatment, HDL- (P <0.05 or P <0.01). There was no significant difference in TG level before and after treatment (P> 0.05). (3) There was no significant correlation between the changes of blood lipid profile and BMI before and after VPA treatment and various risk factors (such as age, gender, mean VPA dosage, etc.) (P> 0.05). Conclusion VPA can lead to abnormal lipid metabolism and BMI in adults with epilepsy.