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目的观察肺特灵Ⅵ号对博莱霉素诱导的小鼠肺纤维化的干预作用。方法采用气管内注入博莱霉素法制备小鼠肺纤维化模型。给药28d后处死,计算肺系数;观察肺脏病理形态学改变,并对肺泡炎和肺纤维化程度进行评分;测定小鼠肺组织中超氧化物歧化酶(SOD)、丙二醛(MDA)、总抗氧化能力(T-AOC)与羟脯氨酸(HYP)等生化指标。结果与模型组相比,肺特灵Ⅵ号各剂量组可明显增加小鼠体质量,降低肺系数,减轻肺泡炎与肺纤维化程度,提高肺组织SOD活性与T-AOC,降低MDA与HYP含量(P<0.05或<0.01)。结论肺特灵Ⅵ号对博莱霉素诱导的小鼠肺纤维化有一定的防治作用。
Objective To observe the effects of Lintong VI on bleomycin-induced pulmonary fibrosis in mice. Methods Pulmonary fibrosis model was induced by intratracheal injection of bleomycin. The rats were sacrificed 28 days after the administration, and the lung coefficient was calculated. The pathological changes of the lungs were observed, and the degree of alveolitis and pulmonary fibrosis was scored. The contents of superoxide dismutase (SOD), malondialdehyde (MDA) Total antioxidant capacity (T-AOC) and hydroxyproline (HYP) and other biochemical indicators. Results Compared with the model group, each dose of lintling VI could significantly increase the body weight, reduce the lung coefficient, reduce the alveolitis and pulmonary fibrosis, improve the SOD activity and T-AOC in the lung tissue, and decrease the MDA and HYP Content (P <0.05 or <0.01). Conclusion Lintong VI has some preventive and therapeutic effects on bleomycin-induced pulmonary fibrosis in mice.