论文部分内容阅读
目的有关不同分子分型的乳腺癌患者化疗后前瞻性记忆(prospective memory,PM)损害是否存在差异,目前尚不清楚。本研究探讨三阴性乳腺癌(triple negative breast cancer,TNBC)患者化疗后基于事件的PM(event-based prospective memory,EBPM)与基于时间的PM(time-based prospective memory,TBPM)损害特征。方法收集2013-01-01-2015-09-30安徽医科大学第二附属医院肿瘤中心接受化疗的乳腺癌化疗后患者244例。其中TNBC 80例,非三阴性乳腺癌(non-triple negative breast cancer,NTNBC)164例。建立EBPM与TBPM的认知神经心理学试验范式,分别进行化疗前后的PM测查。结果与NTNBC患者相比,TNBC患者化疗后EBPM得分0.89±0.86,明显低于NTNBC组的2.59±0.90,差异有统计学意义,Z=-10.61,P<0.01;TNBC和NTNBC患者化疗后TBPM得分别为4.65±0.83和4.80±0.92,差异无统计学意义,Z=-1.48,P>0.05。结论乳腺癌患者化疗后存在不同程度的PM障碍,且TNBC较NTNBC患者EBPM损害更为显著。
Objective It is unclear whether there is any difference in the prospective memory (PM) damage of patients with different molecular types of breast cancer after chemotherapy. This study was to investigate the characteristics of event-based prospective memory (PM) and time-based prospective memory (PM) lesions in patients with triple negative breast cancer (TNBC) after chemotherapy. Methods Totally 244 patients with chemotherapy of breast cancer after chemotherapy were collected at the Cancer Center of the Second Affiliated Hospital of Anhui Medical University from January 2013 to January 2015. There were 80 cases of TNBC and 164 cases of non-triple negative breast cancer (NTNBC). The establishment of EBPM and TBPM cognitive neuropsychological test paradigm, respectively, before and after chemotherapy for PM test. Results Compared with NTNBC patients, the EBPM score of TNBC patients after chemotherapy was 0.89 ± 0.86, which was significantly lower than that of NTNBC patients (2.59 ± 0.90), the difference was statistically significant (Z = -10.61, P <0.01). After TBBC in TNBC and NTNBC patients Respectively, 4.65 ± 0.83 and 4.80 ± 0.92, the difference was not statistically significant, Z = -1.48, P> 0.05. Conclusion There are different degrees of PM disorder after chemotherapy in patients with breast cancer, and the damage of EBPM in TNBC patients is more significant than that in patients with NTNBC.