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核受体是一类配体依赖型转录因子。核受体相互作用蛋白1,又称为受体相互作用蛋白140,与核受体结合后不仅在能量代谢,而且在卵巢排卵功能障碍扮演着重要角色。核受体相互作用蛋白1基因敲除小鼠与临床黄素化未破裂卵泡综合征的表型相同,因而在女性排卵障碍性不孕治疗中备受关注。核受体相互作用蛋白1有望成为排卵障碍治疗和新型避孕药研发的新靶点。就核受体相互作用蛋白1的分子生物学特点、在卵巢排卵中的作用及机制做文献综述。
Nuclear receptors are a class of ligand-dependent transcription factors. Nuclear receptor-interacting protein 1, also known as receptor-interacting protein 140, binds to nuclear receptors not only during energy metabolism but also plays an important role in ovulatory dysfunction. Nuclear receptor interaction protein 1 knockout mice and clinical luteinized unruptured follicle syndrome phenotype, which in women with ovulation disorders infertility treatment has drawn much attention. Nuclear receptor interaction protein 1 is expected to become a new target for the treatment of ovulation disorders and new contraceptives. The molecular biology of nuclear receptor interacting protein 1 and its role in ovarian ovulation and its mechanism were reviewed.