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目的:研究急性心肌梗死(AMI)患者血清线粒体偶联因子-6(CF6)含量在冠状动脉循环中的变化。方法:用放免方法分别测定AMI患者与对照组冠状静脉窦、冠状动脉与外周血清中CF6浓度。结果:AMI患者冠状静脉窦、冠状动脉、外周静脉血清中CF6浓度较对照组差异均有统计学意义(P<0.01),AMI患者冠状静脉窦血清CF6较冠状动脉血清CF6明显升高,差异有统计学意义(P<0.01)。结论:AMI患者外周静脉、冠状动脉和冠状静脉窦血清CF6浓度明显增高,以冠状静脉窦血清CF6升高最明显。
Objective: To investigate the changes of serum mitochondrial coupling factor-6 (CF6) in patients with acute myocardial infarction (AMI) during coronary circulation. Methods: The concentrations of CF6 in the coronary sinus, coronary artery and peripheral blood were measured by radioimmunoassay in AMI patients and controls. Results: There was significant difference of CF6 concentration in coronary sinus, coronary artery and peripheral vein in patients with AMI compared with control group (P <0.01). The level of CF6 in coronary sinus and coronary artery in AMI patients was significantly higher than that in coronary artery Statistical significance (P <0.01). Conclusions: Serum CF6 concentrations in peripheral vein, coronary artery and coronary sinus are significantly increased in patients with AMI, and the most significant increase in coronary sinus serum CF6.