血吸虫病:不涉及免疫机制的小鼠

• 作 者: 王大坤
• 出 处: 国外医学(寄生虫病分册)
• 发表日期: 1990年05期
• 关键词: 血吸虫病 免疫机制 实验动物模型 宿主 细胞介导 曼氏血吸虫 动物实验 大鼠 抗体 血吸虫

在研究血吸虫病免疫机制的动物实验中,最常用的动物是小鼠。然而,一系列新近报告指出,试图从小鼠的血吸虫病模型中获得更多的绪论是存在某些内在危险的。我们对任何现有的实验动物模型是否都值得信赖的争论再来个火上加油。对曼氏血吸虫研究得最多,它的宿主可分为适宜宿主和非适宜宿主。大鼠是非适宜宿主,人、狒狒和小鼠是适宜宿主。在有免疫力的动物,各种抗体依赖性细胞介导的细胞

In animal experiments to study the immune mechanisms of schistosomiasis, the most commonly used animal is the mouse. However, a series of recent reports indicate that there is some inherent risk of trying to gain more introduction from the mouse schistosomiasis model. We’re on the verge of fueling the debate over whether all the existing experimental animal models are trustworthy. Schistosoma mansoni has the most research, its host can be divided into suitable host and non-suitable host. Rats are non-suitable hosts, humans, baboons and mice are suitable hosts. In immunized animals, various antibody-dependent cell-mediated cells