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目的：探讨良恶性卵巢肿瘤患者血脂和糖链抗原水平的诊断和鉴别诊断的临床意义。方法采用生化法和化学发光免疫分析分别测定63例卵巢癌（33例Ⅰ-Ⅱ期，30例Ⅲ-Ⅳ期），76例良性卵巢疾病和57例子宫腺肌病患者以及60名对照组血脂和糖链抗原（CA125、CA153和CA199）水平，并进行对比性研究。结果卵巢癌患者血清TC和HDL-C水平随卵巢癌疾病的严重程度而降低，Ⅰ-Ⅱ期、Ⅲ-Ⅳ期卵巢癌患者均显著低于对照组（P＜0.05，P＜0.01）；良性卵巢疾病患者血清TC和HDL-C显著高于对照组（P均＜0.05）；子宫腺肌病患者血清TC和HDL-C水平与对照组差异无统计学意义（P均＞0.05）。故血清TC和HDL-C水平具有良恶性卵巢肿瘤的诊断和鉴别诊断的临床意义。卵巢癌患者血清CA125、CA153和CA199水平随卵巢疾病的严重程度而增高，Ⅰ-Ⅱ期、Ⅲ-Ⅳ期卵巢癌患者均显著高于对照组（P＜0.05，P＜0.01）。卵巢癌患者血清CA125、CA153和CA199水平均显著高于良性卵巢疾病和子宫腺肌病患者（P均＜0.001），亦具有良恶性卵巢肿瘤的诊断和鉴别诊断的临床意义。结论血清TC、HDL-C和糖链抗原（CA125、CA153和CA199）水平是良恶性卵巢肿瘤患者的诊断和鉴别诊断的有价值指标。“,”ObjectiveTo explore the clinical significance of diagnosis and differential diagnosis by determining blood lipid and serum carbohydrate antigen levels in patients with benign and malignant ovarian tumor.MethodsThe blood lipid and serum carbohydrate antigen (CA125, CA153, CA199) levels were determined by biochemistry and chemiluminescence immune assay in 63 cases ovarian cancer (33 cases stageⅠ-Ⅱ, 30 cases stageⅢ-Ⅳ), 76 cases benign ovarian tumor, 57 cases adenomyosis and 60 normal controls and compared study was done.Results The serum TC and HDL-C levels in ovarian cancer patients decreased with severity. The serum TC and HDL-C levels in stageⅠ-Ⅱ and stageⅢ-Ⅳ ovarian cancer patients were signiifcantly lower than control group (P<0.05,P<0.01), while serum TC and HDL-C levels in patients with benign ovarian tumor signiifcantly increased (P all0.05). So, the serum TC and HDL-C levels had clinical signiifcance in diagnosis and differential diagnosis. The serum CA125, CA153 and CA199 levels in ovarian cancer patients increased with severity. The serum CA125, CA153 and CA199 levels in stageⅠ-Ⅱ and stageⅢ-Ⅳ ovarian cancer patients were significantly higher than control group. The serum CA125, CA153 and CA199 levels in patients with ovarian cancer were significantly higher than those of benign ovarian cancer patients and adenomyosis patients (P all<0.001). So, the serum CA125, CA153 and CA199 levels had clinical signiifcance in diagnosis and differential diagnosis.Conclusion Serum TC, HDL-C and carbohydrate antigen (CA125, CA153 and CA199) were valuable indexes of diagnosis and differential diagnosis in patients with benign and malignant ovarian tumor.