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目的：观察芪麝颈康方对退变颈椎骨赘形成部位碱性磷酸酶活性的影响。方法：选用１０月龄新西兰兔，通过切除动物Ｃ２～Ｃ７棘上韧带、棘间韧带和分离椎旁两侧肌肉，建立颈椎退行性改变的动物模型。组织学观察颈椎椎体骨赘形成的部位，采用生物化学法分别检测颈椎间盘中软骨终板、髓核和纤维环中碱性磷酸酶的活性。结果：证实骨赘来源于软骨终板，中药组退变椎间盘软骨终板中碱性磷酸酶的活性明显低于模型组（Ｐ＜０．０１）。结论：芪麝颈康方可降低骨赘生长部位的碱性磷酸酶活性，推测芪麝颈康方有抑制骨赘形成的作用。
OBJECTIVE: To observe the effect of Qiongkangkang decoction on the alkaline phosphatase activity in the site of degenerated cervical vertebrae. METHODS: Ten-month-old New Zealand rabbits were used to establish an animal model of cervical degenerative changes by removing the C2-C7 supramliac ligaments, interspinous ligaments, and separating the paraspinal muscles. Histology was used to observe the site of osteophyte formation in the cervical vertebrae. The activity of alkaline phosphatase in cartilage endplates, nucleus pulposus, and annulus fibrosus was measured by biochemical methods. RESULTS: It was confirmed that osteophytes were derived from cartilage endplates. The activity of alkaline phosphatase in cartilage endplates of degenerative discs was significantly lower in the TCM group than in the model group (P<0.01). Conclusion: The Jiankangkang decoction can reduce the alkaline phosphatase activity of the epiphyseal growth site, and it is speculated that the Jiankangkang decoction can inhibit the formation of osteophyte.